Treatment of Cognitive, Psychiatric, and Affective Disorders Associated with Parkinson’s Disease
Identifieur interne : 000C31 ( Main/Exploration ); précédent : 000C30; suivant : 000C32Treatment of Cognitive, Psychiatric, and Affective Disorders Associated with Parkinson’s Disease
Auteurs : Barbara Connolly [Canada] ; Susan H. Fox [Canada]Source :
- Neurotherapeutics [ 1933-7213 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Cognition Disorders, Mental Disorders, Mood Disorders.
- therapy : Cognition Disorders, Mental Disorders, Mood Disorders.
- Animals, Humans.
Abstract
Neuropsychiatric symptoms are common in Parkinson’s disease (PD) and add significantly to the burden of disease. These symptoms are most commonly part of the disease spectrum owing to pathological changes within relevant brain regions. Neuropsychiatric problems include disorders of cognition, ranging from mild cognitive impairment to dementia, psychotic symptoms, including, most commonly, well-formed visual hallucinations and paranoid delusions, and mood disorders, such as depression and anxiety. The other common cause of neuropsychiatric problem is secondary to use of dopaminergic drugs. Some PD patients may develop behavioral disorders, including impulse control disorders (ICDs) and addictive symptoms. Psychosis can be due to a mixture of underlying pathology, with triggering or worsening of symptoms with changes to PD medications. Currently, management of these disorders primarily uses therapies developed for general psychiatry and cognitive neurology, rather than specifically for PD. However, significant adverse effects, such as worsening of the motor symptoms of PD, can limit use of some drug therapies. Identification of drug-induced symptoms, such as ICDs, enables withdrawal of the offending drug as the principal management strategy. Research is ongoing in an effort to develop more specific therapies for PD-related neuropsychiatric symptoms.
The online version of this article (doi:10.1007/s13311-013-0238-x) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s13311-013-0238-x
PubMed: 24288035
PubMed Central: 3899484
Affiliations:
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Le document en format XML
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Fox</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Morton and Gloria Shulman Movement Disorder Clinic, University of Toronto, Toronto Western Hospital, 7th Floor, McLaughlin Pavilion, 399 Bathurst Street, Toronto, Ontario M5T 2S8 Canada</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24288035</idno><idno type="pmc">3899484</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899484</idno><idno type="RBID">PMC:3899484</idno><idno type="doi">10.1007/s13311-013-0238-x</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000273</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000273</idno><idno type="wicri:Area/Pmc/Curation">000273</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000273</idno><idno type="wicri:Area/Pmc/Checkpoint">000558</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000558</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000819</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000819</idno><idno type="wicri:Area/PubMed/Curation">000819</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000819</idno><idno type="wicri:Area/PubMed/Checkpoint">000819</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000819</idno><idno type="wicri:Area/Ncbi/Merge">001634</idno><idno type="wicri:Area/Ncbi/Curation">001634</idno><idno type="wicri:Area/Ncbi/Checkpoint">001634</idno><idno type="wicri:doubleKey">1933-7213:2013:Connolly B:treatment:of:cognitive</idno><idno type="wicri:Area/Main/Merge">000C36</idno><idno type="wicri:Area/Main/Curation">000C31</idno><idno type="wicri:Area/Main/Exploration">000C31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment of Cognitive, Psychiatric, and Affective Disorders Associated with Parkinson’s Disease</title><author><name sortKey="Connolly, Barbara" sort="Connolly, Barbara" uniqKey="Connolly B" first="Barbara" last="Connolly">Barbara Connolly</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Hamilton Health Sciences, McMaster University, Hamilton, Ontario Canada</nlm:aff><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H." last="Fox">Susan H. Fox</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Morton and Gloria Shulman Movement Disorder Clinic, University of Toronto, Toronto Western Hospital, 7th Floor, McLaughlin Pavilion, 399 Bathurst Street, Toronto, Ontario M5T 2S8 Canada</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Neurotherapeutics</title><idno type="ISSN">1933-7213</idno><idno type="eISSN">1878-7479</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (therapy)</term><term>Humans</term><term>Mental Disorders (etiology)</term><term>Mental Disorders (therapy)</term><term>Mood Disorders (etiology)</term><term>Mood Disorders (therapy)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Mental Disorders</term><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cognition Disorders</term><term>Mental Disorders</term><term>Mood Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Neuropsychiatric symptoms are common in Parkinson’s disease (PD) and add significantly to the burden of disease. These symptoms are most commonly part of the disease spectrum owing to pathological changes within relevant brain regions. Neuropsychiatric problems include disorders of cognition, ranging from mild cognitive impairment to dementia, psychotic symptoms, including, most commonly, well-formed visual hallucinations and paranoid delusions, and mood disorders, such as depression and anxiety. The other common cause of neuropsychiatric problem is secondary to use of dopaminergic drugs. Some PD patients may develop behavioral disorders, including impulse control disorders (ICDs) and addictive symptoms. Psychosis can be due to a mixture of underlying pathology, with triggering or worsening of symptoms with changes to PD medications. Currently, management of these disorders primarily uses therapies developed for general psychiatry and cognitive neurology, rather than specifically for PD. However, significant adverse effects, such as worsening of the motor symptoms of PD, can limit use of some drug therapies. Identification of drug-induced symptoms, such as ICDs, enables withdrawal of the offending drug as the principal management strategy. Research is ongoing in an effort to develop more specific therapies for PD-related neuropsychiatric symptoms.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s13311-013-0238-x) contains supplementary material, which is available to authorized users.</p></sec></div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Hamilton (Ontario)</li><li>Toronto</li></settlement><orgName><li>Université McMaster</li><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Connolly, Barbara" sort="Connolly, Barbara" uniqKey="Connolly B" first="Barbara" last="Connolly">Barbara Connolly</name></region><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H." last="Fox">Susan H. Fox</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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